It is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health.Caution: Do not use if you have been diagnosed with Bipolar Disorder. Flatulence, nausea, vomiting, diarrhea, constipation, dry mouth, mild insomnia, anorexia, sweating, dizziness and nervousness may occur. Do not use this product within 2 weeks of discontinuing a Monoamine Oxidase Inhibitor (MAOI) drug or if you are pregnant or breastfeeding.

In addition, methylation is required for DNA repair, as well as for the production of SAMe, which helps maintain healthy joint tissue.. NOW Foods TMG (Trimethylglycine) 1000 mg Methylation can be inhibited by poor or inadequate diet and unhealthy lifestyle practices.

Studies suggest it supports joint flexibility and comfort in individuals with osteoarthritis as well. It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity.

Supplement Facts:Serving Size: 1 Tablet         Amount Per ServingS-Adenosyl-L-Methionine (SAMe) Disulfate Tosylate     800 mg- Ionic SAMe     400 mgNon-medicinal ingredients: silicon dioxide, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, ascorbic acid, citric acid (anhydrous), stearic acid, methacrylic acid co-polymer dispersion NF, triethyl citrate, titanium dioxide,  riboflavin, mannitol.